Modulation of asymmetric cell division as a mechanism to boost CD8+ T cell memory.
Identifieur interne : 000274 ( Main/Exploration ); précédent : 000273; suivant : 000275Modulation of asymmetric cell division as a mechanism to boost CD8+ T cell memory.
Auteurs : Mariana Borsa [Suisse] ; Isabel Barnstorf [Suisse] ; Nicolas S. Baumann [Suisse] ; Katharina Pallmer [Suisse] ; Alexander Yermanos [Suisse] ; Fabienne Gr Bnitz [Suisse] ; Nicul Barandun [Suisse] ; Annika Hausmann [Suisse] ; Ioana Sandu [Suisse] ; Yves Barral [Suisse] ; Annette Oxenius [Suisse]Source :
- Science immunology [ 2470-9468 ] ; 2019.
Descripteurs français
- KwdFr :
- Analyse de profil d'expression de gènes (MeSH), Animaux (MeSH), Cellules souches hématopoïétiques (effets des médicaments et des substances chimiques), Cellules souches hématopoïétiques (physiologie), Division cellulaire asymétrique (effets des médicaments et des substances chimiques), Division cellulaire asymétrique (immunologie), Humains (MeSH), Immunothérapie adoptive (méthodes), Infections à Arenaviridae (immunologie), Infections à Arenaviridae (thérapie), Infections à Arenaviridae (virologie), Lymphocytes T CD8+ (effets des médicaments et des substances chimiques), Lymphocytes T CD8+ (immunologie), Lymphocytes T CD8+ (métabolisme), Modèles animaux de maladie humaine (MeSH), Mémoire immunologique (effets des médicaments et des substances chimiques), Régulation de l'expression des gènes (effets des médicaments et des substances chimiques), Régulation de l'expression des gènes (immunologie), Sirolimus (pharmacologie), Sirolimus (usage thérapeutique), Souris (MeSH), Sérine-thréonine kinases TOR (antagonistes et inhibiteurs), Sérine-thréonine kinases TOR (métabolisme), Transduction du signal (effets des médicaments et des substances chimiques), Transduction du signal (immunologie), Virus de la chorioméningite lymphocytaire (immunologie).
- MESH :
- antagonistes et inhibiteurs : Sérine-thréonine kinases TOR.
- effets des médicaments et des substances chimiques : Cellules souches hématopoïétiques, Division cellulaire asymétrique, Lymphocytes T CD8+, Mémoire immunologique, Régulation de l'expression des gènes, Transduction du signal.
- immunologie : Division cellulaire asymétrique, Infections à Arenaviridae, Lymphocytes T CD8+, Régulation de l'expression des gènes, Transduction du signal, Virus de la chorioméningite lymphocytaire.
- métabolisme : Lymphocytes T CD8+, Sérine-thréonine kinases TOR.
- méthodes : Immunothérapie adoptive.
- pharmacologie : Sirolimus.
- physiologie : Cellules souches hématopoïétiques.
- thérapie : Infections à Arenaviridae.
- usage thérapeutique : Sirolimus.
- virologie : Infections à Arenaviridae.
- Analyse de profil d'expression de gènes, Animaux, Humains, Modèles animaux de maladie humaine, Souris.
English descriptors
- KwdEn :
- Animals (MeSH), Arenaviridae Infections (immunology), Arenaviridae Infections (therapy), Arenaviridae Infections (virology), Asymmetric Cell Division (drug effects), Asymmetric Cell Division (immunology), CD8-Positive T-Lymphocytes (drug effects), CD8-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (metabolism), Disease Models, Animal (MeSH), Gene Expression Profiling (MeSH), Gene Expression Regulation (drug effects), Gene Expression Regulation (immunology), Hematopoietic Stem Cells (drug effects), Hematopoietic Stem Cells (physiology), Humans (MeSH), Immunologic Memory (drug effects), Immunotherapy, Adoptive (methods), Lymphocytic choriomeningitis virus (immunology), Mice (MeSH), Signal Transduction (drug effects), Signal Transduction (immunology), Sirolimus (pharmacology), Sirolimus (therapeutic use), TOR Serine-Threonine Kinases (antagonists & inhibitors), TOR Serine-Threonine Kinases (metabolism).
- MESH :
- chemical , antagonists & inhibitors : TOR Serine-Threonine Kinases.
- chemical , metabolism : TOR Serine-Threonine Kinases.
- chemical , pharmacology : Sirolimus.
- drug effects : Asymmetric Cell Division, CD8-Positive T-Lymphocytes, Gene Expression Regulation, Hematopoietic Stem Cells, Immunologic Memory, Signal Transduction.
- immunology : Arenaviridae Infections, Asymmetric Cell Division, CD8-Positive T-Lymphocytes, Gene Expression Regulation, Lymphocytic choriomeningitis virus, Signal Transduction.
- metabolism : CD8-Positive T-Lymphocytes.
- methods : Immunotherapy, Adoptive.
- physiology : Hematopoietic Stem Cells.
- chemical , therapeutic use : Sirolimus.
- therapy : Arenaviridae Infections.
- virology : Arenaviridae Infections.
- Animals, Disease Models, Animal, Gene Expression Profiling, Humans, Mice.
Abstract
Asymmetric partitioning of fate determinants is a mechanism that contributes to T cell differentiation. However, it remains unclear whether the ability of T cells to divide asymmetrically is influenced by their differentiation state, as well as whether enforcing asymmetric cell division (ACD) rates would have an impact on T cell differentiation and memory formation. Using the murine LCMV infection model, we established a correlation between cell stemness and the ability of CD8+ T cells to undergo ACD. Transient mTOR inhibition was proven to increase ACD rates in naïve and memory cells and to install this ability in exhausted CD8+ T cells. Functionally, enforced ACD correlated with increased memory potential, leading to more efficient recall response and viral control upon acute or chronic LCMV infection. Moreover, transient mTOR inhibition also increased ACD rates in human CD8+ T cells. Transcriptional profiling revealed that progenies emerging from enforced ACD exhibited more pronounced early memory signatures, which functionally endowed these cells with better survival in the absence of antigen exposure and more robust homing to secondary lymphoid organs, providing critical access to survival niches. Our data provide important insights into how ACD can improve long-term survival and function of T cells and open new perspectives for vaccination and adoptive T cell transfer therapies.
DOI: 10.1126/sciimmunol.aav1730
PubMed: 30979796
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Modulation of asymmetric cell division as a mechanism to boost CD8<sup>+</sup> T cell memory.</title><author><name sortKey="Borsa, Mariana" sort="Borsa, Mariana" uniqKey="Borsa M" first="Mariana" last="Borsa">Mariana Borsa</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Barnstorf, Isabel" sort="Barnstorf, Isabel" uniqKey="Barnstorf I" first="Isabel" last="Barnstorf">Isabel Barnstorf</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Baumann, Nicolas S" sort="Baumann, Nicolas S" uniqKey="Baumann N" first="Nicolas S" last="Baumann">Nicolas S. Baumann</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Pallmer, Katharina" sort="Pallmer, Katharina" uniqKey="Pallmer K" first="Katharina" last="Pallmer">Katharina Pallmer</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Yermanos, Alexander" sort="Yermanos, Alexander" uniqKey="Yermanos A" first="Alexander" last="Yermanos">Alexander Yermanos</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Gr Bnitz, Fabienne" sort="Gr Bnitz, Fabienne" uniqKey="Gr Bnitz F" first="Fabienne" last="Gr Bnitz">Fabienne Gr Bnitz</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Barandun, Nicul" sort="Barandun, Nicul" uniqKey="Barandun N" first="Nicul" last="Barandun">Nicul Barandun</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Hausmann, Annika" sort="Hausmann, Annika" uniqKey="Hausmann A" first="Annika" last="Hausmann">Annika Hausmann</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Sandu, Ioana" sort="Sandu, Ioana" uniqKey="Sandu I" first="Ioana" last="Sandu">Ioana Sandu</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Barral, Yves" sort="Barral, Yves" uniqKey="Barral Y" first="Yves" last="Barral">Yves Barral</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, ETH Zürich, Otto-Stern-Weg 3, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Biochemistry, ETH Zürich, Otto-Stern-Weg 3, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Oxenius, Annette" sort="Oxenius, Annette" uniqKey="Oxenius A" first="Annette" last="Oxenius">Annette Oxenius</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland. aoxenius@micro.biol.ethz.ch.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30979796</idno><idno type="pmid">30979796</idno><idno type="doi">10.1126/sciimmunol.aav1730</idno><idno type="wicri:Area/Main/Corpus">000298</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000298</idno><idno type="wicri:Area/Main/Curation">000298</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000298</idno><idno type="wicri:Area/Main/Exploration">000298</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Modulation of asymmetric cell division as a mechanism to boost CD8<sup>+</sup> T cell memory.</title><author><name sortKey="Borsa, Mariana" sort="Borsa, Mariana" uniqKey="Borsa M" first="Mariana" last="Borsa">Mariana Borsa</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Barnstorf, Isabel" sort="Barnstorf, Isabel" uniqKey="Barnstorf I" first="Isabel" last="Barnstorf">Isabel Barnstorf</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Baumann, Nicolas S" sort="Baumann, Nicolas S" uniqKey="Baumann N" first="Nicolas S" last="Baumann">Nicolas S. Baumann</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Pallmer, Katharina" sort="Pallmer, Katharina" uniqKey="Pallmer K" first="Katharina" last="Pallmer">Katharina Pallmer</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Yermanos, Alexander" sort="Yermanos, Alexander" uniqKey="Yermanos A" first="Alexander" last="Yermanos">Alexander Yermanos</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Gr Bnitz, Fabienne" sort="Gr Bnitz, Fabienne" uniqKey="Gr Bnitz F" first="Fabienne" last="Gr Bnitz">Fabienne Gr Bnitz</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Barandun, Nicul" sort="Barandun, Nicul" uniqKey="Barandun N" first="Nicul" last="Barandun">Nicul Barandun</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Hausmann, Annika" sort="Hausmann, Annika" uniqKey="Hausmann A" first="Annika" last="Hausmann">Annika Hausmann</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Sandu, Ioana" sort="Sandu, Ioana" uniqKey="Sandu I" first="Ioana" last="Sandu">Ioana Sandu</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Barral, Yves" sort="Barral, Yves" uniqKey="Barral Y" first="Yves" last="Barral">Yves Barral</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, ETH Zürich, Otto-Stern-Weg 3, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Biochemistry, ETH Zürich, Otto-Stern-Weg 3, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Oxenius, Annette" sort="Oxenius, Annette" uniqKey="Oxenius A" first="Annette" last="Oxenius">Annette Oxenius</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland. aoxenius@micro.biol.ethz.ch.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author></analytic><series><title level="j">Science immunology</title><idno type="eISSN">2470-9468</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Arenaviridae Infections (immunology)</term><term>Arenaviridae Infections (therapy)</term><term>Arenaviridae Infections (virology)</term><term>Asymmetric Cell Division (drug effects)</term><term>Asymmetric Cell Division (immunology)</term><term>CD8-Positive T-Lymphocytes (drug effects)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>CD8-Positive T-Lymphocytes (metabolism)</term><term>Disease Models, Animal (MeSH)</term><term>Gene Expression Profiling (MeSH)</term><term>Gene Expression Regulation (drug effects)</term><term>Gene Expression Regulation (immunology)</term><term>Hematopoietic Stem Cells (drug effects)</term><term>Hematopoietic Stem Cells (physiology)</term><term>Humans (MeSH)</term><term>Immunologic Memory (drug effects)</term><term>Immunotherapy, Adoptive (methods)</term><term>Lymphocytic choriomeningitis virus (immunology)</term><term>Mice (MeSH)</term><term>Signal Transduction (drug effects)</term><term>Signal Transduction (immunology)</term><term>Sirolimus (pharmacology)</term><term>Sirolimus (therapeutic use)</term><term>TOR Serine-Threonine Kinases (antagonists & inhibitors)</term><term>TOR Serine-Threonine Kinases (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes (MeSH)</term><term>Animaux (MeSH)</term><term>Cellules souches hématopoïétiques (effets des médicaments et des substances chimiques)</term><term>Cellules souches hématopoïétiques (physiologie)</term><term>Division cellulaire asymétrique (effets des médicaments et des substances chimiques)</term><term>Division cellulaire asymétrique (immunologie)</term><term>Humains (MeSH)</term><term>Immunothérapie adoptive (méthodes)</term><term>Infections à Arenaviridae (immunologie)</term><term>Infections à Arenaviridae (thérapie)</term><term>Infections à Arenaviridae (virologie)</term><term>Lymphocytes T CD8+ (effets des médicaments et des substances chimiques)</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Lymphocytes T CD8+ (métabolisme)</term><term>Modèles animaux de maladie humaine (MeSH)</term><term>Mémoire immunologique (effets des médicaments et des substances chimiques)</term><term>Régulation de l'expression des gènes (effets des médicaments et des substances chimiques)</term><term>Régulation de l'expression des gènes (immunologie)</term><term>Sirolimus (pharmacologie)</term><term>Sirolimus (usage thérapeutique)</term><term>Souris (MeSH)</term><term>Sérine-thréonine kinases TOR (antagonistes et inhibiteurs)</term><term>Sérine-thréonine kinases TOR (métabolisme)</term><term>Transduction du signal (effets des médicaments et des substances chimiques)</term><term>Transduction du signal (immunologie)</term><term>Virus de la chorioméningite lymphocytaire (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Asymmetric Cell Division</term><term>CD8-Positive T-Lymphocytes</term><term>Gene Expression Regulation</term><term>Hematopoietic Stem Cells</term><term>Immunologic Memory</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Cellules souches hématopoïétiques</term><term>Division cellulaire asymétrique</term><term>Lymphocytes T CD8+</term><term>Mémoire immunologique</term><term>Régulation de l'expression des gènes</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Division cellulaire asymétrique</term><term>Infections à Arenaviridae</term><term>Lymphocytes T CD8+</term><term>Régulation de l'expression des gènes</term><term>Transduction du signal</term><term>Virus de la chorioméningite lymphocytaire</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Arenaviridae Infections</term><term>Asymmetric Cell Division</term><term>CD8-Positive T-Lymphocytes</term><term>Gene Expression Regulation</term><term>Lymphocytic choriomeningitis virus</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunotherapy, Adoptive</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphocytes T CD8+</term><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Immunothérapie adoptive</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cellules souches hématopoïétiques</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hematopoietic Stem Cells</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Arenaviridae Infections</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Infections à Arenaviridae</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à Arenaviridae</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Arenaviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Gene Expression Profiling</term><term>Humans</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Animaux</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Asymmetric partitioning of fate determinants is a mechanism that contributes to T cell differentiation. However, it remains unclear whether the ability of T cells to divide asymmetrically is influenced by their differentiation state, as well as whether enforcing asymmetric cell division (ACD) rates would have an impact on T cell differentiation and memory formation. Using the murine LCMV infection model, we established a correlation between cell stemness and the ability of CD8<sup>+</sup> T cells to undergo ACD. Transient mTOR inhibition was proven to increase ACD rates in naïve and memory cells and to install this ability in exhausted CD8<sup>+</sup> T cells. Functionally, enforced ACD correlated with increased memory potential, leading to more efficient recall response and viral control upon acute or chronic LCMV infection. Moreover, transient mTOR inhibition also increased ACD rates in human CD8<sup>+</sup> T cells. Transcriptional profiling revealed that progenies emerging from enforced ACD exhibited more pronounced early memory signatures, which functionally endowed these cells with better survival in the absence of antigen exposure and more robust homing to secondary lymphoid organs, providing critical access to survival niches. Our data provide important insights into how ACD can improve long-term survival and function of T cells and open new perspectives for vaccination and adoptive T cell transfer therapies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30979796</PMID><DateCompleted><Year>2020</Year><Month>04</Month><Day>02</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>02</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2470-9468</ISSN><JournalIssue CitedMedium="Internet"><Volume>4</Volume><Issue>34</Issue><PubDate><Year>2019</Year><Month>04</Month><Day>12</Day></PubDate></JournalIssue><Title>Science immunology</Title><ISOAbbreviation>Sci Immunol</ISOAbbreviation></Journal><ArticleTitle>Modulation of asymmetric cell division as a mechanism to boost CD8<sup>+</sup> T cell memory.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">eaav1730</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1126/sciimmunol.aav1730</ELocationID><Abstract><AbstractText>Asymmetric partitioning of fate determinants is a mechanism that contributes to T cell differentiation. However, it remains unclear whether the ability of T cells to divide asymmetrically is influenced by their differentiation state, as well as whether enforcing asymmetric cell division (ACD) rates would have an impact on T cell differentiation and memory formation. Using the murine LCMV infection model, we established a correlation between cell stemness and the ability of CD8<sup>+</sup> T cells to undergo ACD. Transient mTOR inhibition was proven to increase ACD rates in naïve and memory cells and to install this ability in exhausted CD8<sup>+</sup> T cells. Functionally, enforced ACD correlated with increased memory potential, leading to more efficient recall response and viral control upon acute or chronic LCMV infection. Moreover, transient mTOR inhibition also increased ACD rates in human CD8<sup>+</sup> T cells. Transcriptional profiling revealed that progenies emerging from enforced ACD exhibited more pronounced early memory signatures, which functionally endowed these cells with better survival in the absence of antigen exposure and more robust homing to secondary lymphoid organs, providing critical access to survival niches. Our data provide important insights into how ACD can improve long-term survival and function of T cells and open new perspectives for vaccination and adoptive T cell transfer therapies.</AbstractText><CopyrightInformation>Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Borsa</LastName><ForeName>Mariana</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barnstorf</LastName><ForeName>Isabel</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baumann</LastName><ForeName>Nicolas S</ForeName><Initials>NS</Initials><Identifier Source="ORCID">0000-0002-6619-6291</Identifier><AffiliationInfo><Affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pallmer</LastName><ForeName>Katharina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yermanos</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gräbnitz</LastName><ForeName>Fabienne</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barandun</LastName><ForeName>Niculò</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hausmann</LastName><ForeName>Annika</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0001-8852-3444</Identifier><AffiliationInfo><Affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sandu</LastName><ForeName>Ioana</ForeName><Initials>I</Initials><Identifier Source="ORCID">0000-0003-4696-0683</Identifier><AffiliationInfo><Affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barral</LastName><ForeName>Yves</ForeName><Initials>Y</Initials><Identifier Source="ORCID">0000-0002-0989-3373</Identifier><AffiliationInfo><Affiliation>Institute of Biochemistry, ETH Zürich, Otto-Stern-Weg 3, 8093 Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oxenius</LastName><ForeName>Annette</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0002-2079-2354</Identifier><AffiliationInfo><Affiliation>Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland. aoxenius@micro.biol.ethz.ch.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Sci Immunol</MedlineTA><NlmUniqueID>101688624</NlmUniqueID><ISSNLinking>2470-9468</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="C546842">MTOR protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="C546843">mTOR protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber><NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001117" MajorTopicYN="N">Arenaviridae Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D060049" MajorTopicYN="N">Asymmetric Cell Division</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018414" MajorTopicYN="N">CD8-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020869" MajorTopicYN="N">Gene Expression Profiling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006412" MajorTopicYN="N">Hematopoietic Stem Cells</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007156" MajorTopicYN="N">Immunologic Memory</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016219" MajorTopicYN="N">Immunotherapy, Adoptive</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008217" MajorTopicYN="N">Lymphocytic choriomeningitis virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>08</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>02</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>4</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>4</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30979796</ArticleId><ArticleId IdType="pii">4/34/eaav1730</ArticleId><ArticleId IdType="doi">10.1126/sciimmunol.aav1730</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Suisse</li></country><region><li>Canton de Zurich</li></region><settlement><li>Zurich</li></settlement></list><tree><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Borsa, Mariana" sort="Borsa, Mariana" uniqKey="Borsa M" first="Mariana" last="Borsa">Mariana Borsa</name></region><name sortKey="Barandun, Nicul" sort="Barandun, Nicul" uniqKey="Barandun N" first="Nicul" last="Barandun">Nicul Barandun</name><name sortKey="Barnstorf, Isabel" sort="Barnstorf, Isabel" uniqKey="Barnstorf I" first="Isabel" last="Barnstorf">Isabel Barnstorf</name><name sortKey="Barral, Yves" sort="Barral, Yves" uniqKey="Barral Y" first="Yves" last="Barral">Yves Barral</name><name sortKey="Baumann, Nicolas S" sort="Baumann, Nicolas S" uniqKey="Baumann N" first="Nicolas S" last="Baumann">Nicolas S. Baumann</name><name sortKey="Gr Bnitz, Fabienne" sort="Gr Bnitz, Fabienne" uniqKey="Gr Bnitz F" first="Fabienne" last="Gr Bnitz">Fabienne Gr Bnitz</name><name sortKey="Hausmann, Annika" sort="Hausmann, Annika" uniqKey="Hausmann A" first="Annika" last="Hausmann">Annika Hausmann</name><name sortKey="Oxenius, Annette" sort="Oxenius, Annette" uniqKey="Oxenius A" first="Annette" last="Oxenius">Annette Oxenius</name><name sortKey="Pallmer, Katharina" sort="Pallmer, Katharina" uniqKey="Pallmer K" first="Katharina" last="Pallmer">Katharina Pallmer</name><name sortKey="Sandu, Ioana" sort="Sandu, Ioana" uniqKey="Sandu I" first="Ioana" last="Sandu">Ioana Sandu</name><name sortKey="Yermanos, Alexander" sort="Yermanos, Alexander" uniqKey="Yermanos A" first="Alexander" last="Yermanos">Alexander Yermanos</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000274 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000274 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= RapamycinFungusV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:30979796
|texte= Modulation of asymmetric cell division as a mechanism to boost CD8+ T cell memory.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:30979796" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
| This area was generated with Dilib version V0.6.38. |  |